Structure-activity relationships (SAR) analysis is crucial in drug discovery. By systematically modifying the chemical structure of a lead compound and observing the resulting biological activity, researchers identify the key structural features responsible for desired effects. This knowledge directs further optimization of novel therapeutic agents

The treatment of chronic pain often involves a multi-faceted approach, incorporating pharmacological interventions designed to modulate various neural pathways involved in pain perception and transmission. Commonly employed drug classes include nonsteroidal anti-inflammatory drugs (NSAIDs), which exert their pain-relieving effects by inhibiting cyc